Inflammatory bowel disease (IBD) is a chronic condition that affects the digestive tract, causing inflammation and damage to the lining of the intestines. It includes two main types: Crohn’s disease and ulcerative colitis. While the exact cause of IBD is unknown, it is believed to involve a combination of genetic, environmental, and immune system factors.

One potential supplement that has gained attention in recent years for its potential benefits in managing IBD is L-glutamine. L-glutamine is an amino acid that is naturally produced in the body and plays a crucial role in various bodily functions, including the health of the digestive system.

Research suggests that L-glutamine may have several beneficial effects on IBD. Firstly, it is known to support the integrity of the intestinal lining. In IBD, the lining of the intestines becomes damaged, leading to increased permeability and allowing harmful substances to enter the bloodstream. L-glutamine has been shown to help repair and strengthen the intestinal barrier, reducing this permeability and preventing the entry of toxins.

Furthermore, L-glutamine has been found to have anti-inflammatory properties. Inflammation is a hallmark of IBD and contributes to the symptoms experienced by patients. Studies have shown that L-glutamine can help reduce the production of pro-inflammatory molecules and promote the release of anti-inflammatory substances, thereby dampening the inflammatory response in the intestines.

Additionally, L-glutamine has been found to support the immune system, which is often dysregulated in individuals with IBD. It can help modulate the activity of immune cells, promoting a balanced immune response and reducing excessive inflammation.

While the research on L-glutamine and IBD is promising, it is important to note that it should not be used as a standalone treatment for the condition. IBD is a complex disease that requires a comprehensive approach, including medication, dietary changes, and lifestyle modifications. However, L-glutamine may serve as a valuable adjunct therapy to help manage symptoms and improve the overall health of the digestive system.

When considering L-glutamine supplementation, it is important to choose a high-quality product from a reputable source such as Chesapeake Express IV, who has high quality trained staff and uses We Care Pharmacy in VA for it’s all natural, preservative free L-Glutamine. Look for supplements that are third-party tested for purity and potency to ensure you are getting a reliable and effective product. The best thing about IV L-Glutamine is that 100% absorption is guaranteed.

In addition to L-glutamine, it is important to focus on a well-balanced diet and lifestyle modifications to manage IBD effectively. This may include avoiding trigger foods, incorporating anti-inflammatory foods, managing stress levels, getting regular exercise, and ensuring adequate hydration.

In conclusion, L-glutamine shows promise as a supplement for individuals with inflammatory bowel disease. Its ability to support the integrity of the intestinal lining, reduce inflammation, and modulate the immune system makes it a potentially valuable addition to an overall treatment plan. However, it is important to consult with a healthcare professional before starting any new supplement and to use it in conjunction with other therapies for optimal results.


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2. Coëffier M, Marion-Letellier R, Déchelotte P. Potential for amino acids supplementation during inflammatory bowel diseases. Inflamm Bowel Dis. 2010;16(3):518-524. doi:10.1002/ibd.21082

3. Ziegler TR. Glutamine supplementation in inflammatory bowel disease: a new perspective. Nutrition. 2001;17(11-12):892-895. doi:10.1016/s0899-9007(01)00642-0

4. Benjamin J, Makharia G, Ahuja V. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn’s disease: a randomized controlled trial. Dig Dis Sci. 2012;57(4):1000-1012. doi:10.1007/s10620-011-1981-3

5. Akobeng AK, Elawad M, Gordon M. Glutamine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2016;4(4):CD007348. doi:10.1002/14651858.CD007348.pub3

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